Dr. Sangeeta Murugkar

Associate Professor, Medical Physics
Physics Department - Carleton University
2414 HP
(613) 520 - 2600 Ext. 4016
smurugkaratphysics [dot] carleton [dot] ca

Light interacts with living systems at the molecular level, with ultra-high spatial and temporal resolution; this renders optical imaging and spectroscopy ideal for investigating disease mechanisms. My research interest focuses on developing novel optical microscopy and spectroscopy techniques for studying the molecular basis of disease and its early detection. Examples of such techniques include multimodal optical microscopy and spectroscopy techniques such as coherent Raman imaging, two-photon fluorescence imaging, second harmonic generation imaging and Raman spectroscopy. I am keen on translating these optical techniques from the benchtop to the bedside in a compact endoscopic platform. I am also interested in using gold nanoparticles for live cell molecular imaging and biosensing applications.


 Selected Publications


  • Santa Borel, Emil A. Prikryl*, Nhung Vuong, James Jonkman, Barbara Vanderhyden, Brian C. Wilson and Sangeeta Murugkar, "Live-cell Raman microspectroscopy to differentiate between normal and malignant mouse ovarian surface epithelial cells", Analytical Methods, DOI: 10.1039/C5AY02462E (2015).
  • Simon-Alexandre Lussier*, Hamid Moradi*, Alain Price* and Sangeeta Murugkar, "Imaging highly absorbing nanoparticles using photothermal microscopy", Proc. SPIE Vol. 9337 93370N1-5 (2015). 
  • M. Naji*, S. Murugkar, H. Anis, "Determining optimum operating conditions of the polarization maintaining fiber with two far-lying zero dispersion wavelengths for CARS microscopy", Optics Express, 22(9), 10800-10814 (2014).
  • J. Upham, I. De Leon, D. Grobnic, E. Ma*, MC Dicaire, SA Schulz, S. Murugkar, RW Boyd, "Enhancing optical field intensities in Gaussian-profile fiber Bragg gratings", Optics Letters 39(4), 849-52 (2014).
  • B. Smith, M. Naji, S. Murugkar, Emilio Alarcon, C. Brideau, P. Stys, H. Anis, “Portable, miniaturized, fibre delivered, multimodal CARS exoscope”, Optics Express 21, 17161-17175 (2013).
  • Sangeeta Murugkar, Israel De Leon, Matthew Horton, Hammam Qassim, Jonathan Leach and Robert W. Boyd, “Planar chiral metamaterials for biosensing applications”, Proc. SPIE 8597 85970Y (2013).
  • S. Murugkar, B. Smith, P. Srivastava, A. Moica, C. Brideau, P. Stys, H. Anis, “Miniaturized multimodal CARS microscope based on MEMS scanning and a single laser source”, Optics Express 18, 23796 (2010) {selected for publication in the Virtual Journal of Biomedical Optics Vol. 6(1) (Jan 3 2011)}.
  • S. Murugkar, C. Evans, S. Xie, H. Anis, “Chemically specific imaging of cryptosporidium oocysts using coherent anti-Stokes Raman scattering (CARS) microscopy”, Journal of microscopy 233, 244 - 250 (2009).
  • S. Murugkar, C. Brideau, A. Ridsdale, M. Naji, P. Stys, H. Anis, “Coherent anti-Stokes Raman scattering microscopy using photonic crystal fiber with two closely lying zero dispersion wavelengths”, Optics Express 15, 14028 (2007).