Dr. Greg O. Cron

The Ottawa Hospital Department of Medical Imaging, The Ottawa Hospital Research Institute MRI Unit - Department of Medical Imaging - Ottawa Hospital
(613) 737-8899 x 77701

About Dr. Greg O. Cron

Dr. Cron was born in Columbus, Ohio, USA. He received a BSc in physics and mathematics from Xavier University in Cincinnati, Ohio in 1993. He went on to cam his MSc (1995) and PhD (2000) in medical physics from The University of Wisconsin - Madison. Dr. Cron worked a post-doctoral fellow at Carleton University (2001-2003) and The Catholic University of Louvain in Brussels, Belgium (2004-2005). Following that, in 2006 he moved back to Ottawa for a position as senior clinical research associate at The Ottawa Hospital. In 2011 Dr. Cron became an assistant professor at the University of Ottawa Faculty of Medicine's Department of Radiology. In 2016 he was promoted to the position of Facility Manager for the University of Ottawa Pre-Clincial Imaging Core. Dr. Cron's main research interests are in Magnetic Resonance Imaging with special emphasis on the development of techniques for measuring blood flow (perfusion) quantitatively, primarity for cancer research.


List of Publications:

  1. Tomlinson JJ, Shutinoski B, Dong L, Meng F, Elleithy D, Lengacher NA, Nguyen
     AP, Cron GO, Jiang Q, Roberson ED, Nussbaum RL, Majbour NK, El-Agnaf OM, Bennett SA, Lagace DC, Woulfe JM, Sad S, Brown EG, Schlossmacher MG. Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects. J Neural Transm (Vienna). 2017 Jun;124(6):721-738. doi:10.1007/s00702-017-1726-7. Epub 2017 May 5. PubMed PMID: 28477284.

  2. Alkayyal AA, Tai LH, Kennedy MA, de Souza CT, Zhang J, Lefebvre C, Sahi S, Ananth AA, Mahmoud AB, Makrigiannis AP, Cron GO, Macdonald B, Marginean EC, Stojdl DF, Bell JC, Auer RC. NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine. Cancer Immunol Res. 2017 Mar;5(3):211-221. doi: 10.1158/2326-6066.CIR-16-0162. Epub 2017 Feb 3. PubMed PMID: 28159747.

  3. Trudel G, Melkus G, Cron GO, Louati H, Sheikh A, Larson PE, Schweitzer M, Lapner P, Uhthoff HK, Laneuville O. Imaging of the rabbit supraspinatus enthesis at 7 Tesla: a 4-week time course after repair surgery and effect of channeling. J Magn Reson Imaging. 2017 Feb 2. doi: 10.1002/jmri.25589. [Epub ahead of print] PubMed PMID: 28152242.

  4. Nguyen TB, Cron GO, Bezzina K, Perdrizet K, Torres CH, Chakraborty S, Woulfe J, Jansen GH, Thornhill RE, Zanette B, Cameron IG. Correlation of Tumor Immunohistochemistry with Dynamic Contrast-Enhanced and DSC-MRI Parameters in Patients with Gliomas. AJNR Am J Neuroradiol. 2016 Dec;37(12):2217-2223. Epub 2016 Sep 1. PubMed PMID: 27585700.

  5. Thibodeau JF, Holterman CE, He Y, Carter A, Cron GO, Boisvert NC, Abd-Elrahman KS, Hsu KJ, Ferguson SS, Kennedy CR. Vascular Smooth Muscle-Specific EP4 Receptor Deletion in Mice Exacerbates Angiotensin II-Induced Renal Injury. Antioxid Redox Signal. 2016 Oct 20;25(12):642-656. Epub 2016 Aug 5. PubMed PMID: 27245461.

  6. Anwander H, Cron GO, Rakhra K, Beaule PE. Perfusion MRI in hips with metal-on-metal and metal-on-polyethylene total hip arthroplasty: A pilot study. Bone Joint Res. 2016 Mar;5(3):73-9. doi: 10.1302/2046-3758.53.2000572. PubMed PMID: 26935768; PubMed Central PMCID: PMC4852810.

  7. Schieda N, Dilauro M, Moosavi B, Hodgdon T, Cron GO, McInnes MD, Flood TA. MRI evaluation of small (<4cm) solid renal masses: multivariate modeling improves diagnostic accuracy for angiomyolipoma without visible fat compared to univariate analysis. Eur Radiol. 2016 Jul;26(7):2242-51. doi: 10.1007/s00330-015-4039-y. Epub 2015 Oct 20. PubMed PMID: 26486936.

  8. Nguyen TB, Cron GO, Perdrizet K, Bezzina K, Torres CH, Chakraborty S, Woulfe J, Jansen GH, Sinclair J, Thornhill RE, Foottit C, Zanette B, Cameron IG. Comparison of the Diagnostic Accuracy of DSC- and Dynamic Contrast-Enhanced MRI in the Preoperative Grading of Astrocytomas. AJNR Am J Neuroradiol. 2015 Nov;36(11):2017-22. doi: 10.3174/ajnr.A4398. Epub 2015 Jul 30. PubMed PMID:26228886.

  9. Ahmadi A, Thorn SL, Alarcon EI, Kordos M, Padavan DT, Hadizad T, Cron GO, Beanlands RS, DaSilva JN, Ruel M, deKemp RA, Suuronen EJ. PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction. Biomaterials. 2015 May;49:18-26. doi: 10.1016/j.biomaterials.2015.01.016. Epub 2015 Feb 11. PubMed PMID: 25725551.

  10. Fruytier AC, Magat J, Neveu MA, Karroum O, Bouzin C, Feron O, Jordan B, Cron GO, Gallez B. Dynamic contrast-enhanced MRI in mouse tumors at 11.7 T: comparison of three contrast agents with different molecular weights to assess the early effects of combretastatin A4. NMR Biomed. 2014 Nov;27(11):1403-12. doi:10.1002/nbm.3220. PubMed PMID: 25323069.

  11. Thornhill RE, Golfam M, Sheikh A, Cron GO, White EA, Werier J, Schweitzer ME, Di Primio G. Differentiation of lipoma from liposarcoma on MRI using texture and shape analysis. Acad Radiol. 2014 Sep;21(9):1185-94. doi:10.1016/j.acra.2014.04.005. PubMed PMID: 25107867.

  12. Coffey N, Schieda N, Cron G, Gulavita P, Mai KT, Flood TA. Multi-parametric (mp) MRI of prostatic ductal adenocarcinoma. J Magn Reson Imaging. 2015 Jun;41(6):1639-45. doi: 10.1002/jmri.24694. Epub 2014 Jul 10. PubMed PMID: 25044687.

  13. Nguyen TB, Cron GO, Mercier JF, Foottit C, Torres CH, Chakraborty S, Woulfe J, Jansen GH, Caudrelier JM, Sinclair J, Hogan MJ, Thornhill RE, Cameron IG.Preoperative prognostic value of dynamic contrast-enhanced MRI-derived contrast transfer coefficient and plasma volume in patients with cerebral gliomas. AJNR Am J Neuroradiol. 2015 Jan;36(1):63-9. doi: 10.3174/ajnr.A4006. Epub 2014 Jun 19. PubMed PMID: 24948500.

  14. Caron AZ, He X, Mottawea W, Seifert EL, Jardine K, Dewar-Darch D, Cron GO, Harper ME, Stintzi A, McBurney MW. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. FASEB J. 2014 Mar;28(3):1306-16. doi:10.1096/fj.13-243568. Epub 2013 Dec 2. PubMed PMID: 24297700.

  15. Fruytier AC, Magat J, Colliez F, Jordan B, Cron G, Gallez B. Dynamic contrast-enhanced MRI in mice at high field: estimation of the arterial input function can be achieved by phase imaging. Magn Reson Med. 2014 Feb;71(2):544-50. doi: 10.1002/mrm.24682. Erratum in: Magn Reson Med. 2014 Aug;72(2):602. PubMed PMID: 23440927.

  16. Nguyen TB, Cron GO, Mercier JF, Foottit C, Torres CH, Chakraborty S, Woulfe J, Jansen GH, Caudrelier JM, Sinclair J, Hogan MJ, Thornhill RE, Cameron IG. Diagnostic accuracy of dynamic contrast-enhanced MR imaging using a phase-derived vascular input function in the preoperative grading of gliomas. AJNR Am J Neuroradiol. 2012 Sep;33(8):1539-45. doi: 10.3174/ajnr.A3012. Epub 2012 Mar 22. PubMed PMID: 22442046.

  17. Cron GO, Foottit C, Yankeelov TE, Avruch LI, Schweitzer ME, Cameron I. Arterial input functions determined from MR signal magnitude and phase for quantitative dynamic contrast-enhanced MRI in the human pelvis. Magn Reson Med. 2011 Aug;66(2):498-504. doi: 10.1002/mrm.22856. Epub 2011 Feb 28. PubMed PMID: 21360747.

  18. Magat J, Jordan BF, Cron GO, Gallez B. Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using 19F MRI. Med Phys. 2010 Oct;37(10):5434-41. PubMed PMID: 21089779.

  19. Magat J, Jordan BF, Cron GO, Gallez B. Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using F19 MRI. Med Phys. 2010 Oct;37(10):5434-5441. doi: 10.1118/1.3484056. PubMed PMID: 28524524.

  20. Foottit C, Cron GO, Hogan MJ, Nguyen TB, Cameron I. Determination of the venous output function from MR signal phase: feasibility for quantitative DCE-MRI in human brain. Magn Reson Med. 2010 Mar;63(3):772-81. doi: 10.1002/mrm.22253. PubMed PMID: 20187184.

  21. Jordan BF, Cron GO, Gallez B. Rapid monitoring of oxygenation by 19F magnetic resonance imaging: Simultaneous comparison with fluorescence quenching. Magn Reson Med. 2009 Mar;61(3):634-8. doi: 10.1002/mrm.21594. PubMed PMID: 19097235.

  22. Cron GO, Beghein N, Ansiaux R, Martinive P, Feron O, Gallez B. 19F NMR in vivo spectroscopy reflects the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy. Magn Reson Med. 2008 Jan;59(1):19-27. PubMed PMID: 18050344.

  23. Yankeelov TE, Cron GO, Addison CL, Wallace JC, Wilkins RC, Pappas BA, Santyr GE, Gore JC. Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Magn Reson Med. 2007 Feb;57(2):353-61. PubMed PMID: 17260371.

  24. Crokart N, Jordan BF, Baudelet C, Cron GO, Hotton J, Radermacher K, Grégoire V, Beghein N, Martinive P, Bouzin C, Feron O, Gallez B. Glucocorticoids modulate tumor radiation response through a decrease in tumor oxygen consumption. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):630-5. PubMed PMID: 17255286.

  25. Baudelet C, Cron GO, Gallez B. Determination of the maturity and functionality of tumor vasculature by MRI: correlation between BOLD-MRI and DCE-MRI using P792 in experimental fibrosarcoma tumors. Magn Reson Med. 2006 Nov;56(5):1041-9. PubMed PMID: 16986109.

  26. Jordan BF, Crokart N, Baudelet C, Cron GO, Ansiaux R, Gallez B. Complex relationship between changes in oxygenation status and changes in R*2: the case of insulin and NS-398, two inhibitors of oxygen consumption. Magn Reson Med. 2006 Sep;56(3):637-43. PubMed PMID: 16897769.

  27. Abdeen N, Cross A, Cron G, White S, Rand T, Miller D, Santyr G. Measurement of xenon diffusing capacity in the rat lung by hyperpolarized 129Xe MRI and dynamic spectroscopy in a single breath-hold. Magn Reson Med. 2006 Aug;56(2):255-64. PubMed PMID: 16767751.

  28.  Ansiaux R, Baudelet C, Cron GO, Segers J, Dessy C, Martinive P, De Wever J, Verrax J, Wauthier V, Beghein N, Grégoire V, Buc Calderon P, Feron O, Gallez B. Botulinum toxin potentiates cancer radiotherapy and chemotherapy. Clin Cancer Res. 2006 Feb 15;12(4):1276-83. PubMed PMID: 16489084.

  29. audelet C, Cron GO, Ansiaux R, Crokart N, DeWever J, Feron O, Gallez B. The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors. NMR Biomed. 2006 Feb;19(1):69-76. PubMed PMID: 16411170.

  30. Cron GO, Beghein N, Crokart N, Chavée E, Bernard S, Vynckier S, Scalliet P, Gallez B. Changes in the tumor microenvironment during low-dose-rate permanent seed implantation iodine-125 brachytherapy. Int J Radiat Oncol Biol Phys. 2005 Nov 15;63(4):1245-51. PubMed PMID: 16253779.

  31. Crokart N, Radermacher K, Jordan BF, Baudelet C, Cron GO, Grégoire V, Beghein N, Bouzin C, Feron O, Gallez B. Tumor radiosensitization by antiinflammatory drugs: evidence for a new mechanism involving the oxygen effect. Cancer Res. 2005 Sep 1;65(17):7911-6. PubMed PMID: 16140962.

  32. Cron GO, Wallace JC, Stevens WD, Fortin T, Pappas BA, Wilkins RC, Kelcz F, Santyr GE. A comparison of T2*-weighted magnitude and phase imaging for measuring the arterial input function in the rat aorta following intravenous injection of gadolinium contrast agent. Magn Reson Imaging. 2005 Jun;23(5):619-27. PubMed PMID: 16051036.

  33. Cron GO, Kelcz F, Santyr GE. Improvement in breast lesion characterization with dynamic contrast-enhanced MRI using pharmacokinetic modeling and bookend T(1) measurements. Magn Reson Med. 2004 May;51(5):1066-70. PubMed PMID: 15122692.

  34. Cron GO, Santyr G, Kelcz F. Accurate and rapid quantitative dynamic contrast-enhanced breast MR imaging using spoiled gradient-recalled echoes and bookend T(1) measurements. Magn Reson Med. 1999 Oct;42(4):746-53. PubMed PMID: 10502764.

  35. Kelcz F, Santyr GE, Cron GO, Mongin SJ. Application of a quantitative model to differentiate benign from malignant breast lesions detected by dynamic, gadolinium-enhanced MRI. J Magn Reson Imaging. 1996 Sep-Oct;6(5):743-52. PubMed PMID: 8890012.

  36.  Sonzogni AA, Elmaani A, Hyde-Wright C, Jiang W, Prindle D, Vandenbosch R, Dinius J, Cron G, Bowman D, Gelbke CK, Hsi W, Lynch WG, Montoya C, Peaslee G, Schwarz C, Tsang MB, Williams C, DeSouza R, Fox D, Moore T. Evaporation residue, fission cross sections, and linear momentum transfer for 14N induced reactions from 35A to 155A MeV. Phys Rev C Nucl Phys. 1996 Jan;53(1):243-248. PubMed PMID: 9970934.

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