Dr. Ian G. Cameron

Research Summary

Dr. Cameron is currently not accepting any new graduate students.

With Magnetic Resonance Imaging (MRI), "pictures" of the inside of the body are obtained noninvasively. The signals from which these MR images are made are generated mainly by 1H nuclei of water. MRI has become a vital part of diagnostic medicine, especially for head, spine and joint imaging. Two areas of MRI research, which are available for graduate student involvement, are diffusion MRI and perfusion MRI. Most of this work will be done on the MR imagers at the Ottawa Hospital.

Contrast between tissues in an MR image is a result of differences in inherent tissue parameters such as NMR relaxation times or water diffusion coefficients (D) between tissues, however, the physics of exactly how these processes contribute to the contrast is often unclear. MR diffusion measurements are rich in information about the microscopic environment of the cells. The challenge is to extract this information and display it in a meaningful way. Currently our focus is on separating the intracellular behaviour from the extracelluar dynamics for human brain white matter in vivo and to study the exchange of water between these two environments.

Currently, MR techniques for measuring blood perfusion (slow blood flow through capillaries) are qualitative but there is a clinical need for quantitative brain perfusion MRI, especially as it pertains to stroke. That is the goal of this project.

Publications/Presentations

1. Preoperative Determination of Isocitrate Dehydrogenase Mutation in Gliomas Using Spectral Edited MRS: A Prospective Study, T.B. Nguyen, G. Melkus, M. Taccone, I.D. Moldovan, D. Ghinda, R Gotfrit, C.H. Torres, N. Zakhari, S. Chakraborty, J. Woulfe, G. Jansen, M.D. McInnes, R.E. Thornhill, I.G. Cameron, F. AlKherayf, J. Magn. Reson. Imaging (online ahead of print, Sep 2020). DOI: https://doi.org/10.1002/jmri.27366

2. T. Hatchard, A. Byron-Alhassan, O. Mioduszewski, K. Holshausen, S. Correia, A. Leeming, G. Ayson, C. Chiasson, P. Fried, I.G. Cameron, A.M. Smith, Working Overtime:

Altered Functional Connectivity in Working Memory Following Regular Cannabis Use in Young Adults, International Journal of Mental Health and Addiction, (Published online 4 April 2020). DOI: https://doi.org/10.1007/s11469-020-00226-y

3. J. Berard, Z. Fang, L. Walker, A. Lindsay-Brown, L. Osman, I.G. Cameron, R. Cruce, G.O. Cron, M. Freedman, A.M. Smith, Imaging Cognitive Fatigability in Multiple Sclerosis: Objective Quantification of Cerebral Blood Flow During a Task of Sustained Attention Using ASL Perfusion fMRI, Brain Imaging and Behavior, (Aug 2019). PMID: 31468375, DOI: http://doi.org/10.1007/s11682-019-00192-7

4. T.B. Nguyen, G.O. Cron, K. Perdrizet, K. Bezzina, C.H. Torres, S. Chakraborty, J. Woulfe, G.H. Jansen, J. Sinclair, R.E. Thornhill, C. Foottit, B. Zanette, I.G. Cameron, Comparison of the Diagnostic Accuracy of DSC- and Dynamic Contrast Enhanced MRI in the Preoperative Grading of Astrocytomas, American Journal of Neuroradiology 36(11), 2017-2022 (Nov 2015) - 29 citations. PMID 26228886; DOI: 10.3174/ajnr.A4398.

5. K.S. Rakhra, A. Cárdenas-Blanco, G. Melkus, M.E. Schweitzer, I.G. Cameron, P.E. Beaulé, Is the T1ρ MRI Profile of Hyaline Cartilage in the Normal Hip Uniform?, Clinical Orthopaedics and Related Research 473(4), 1325-32 (Apr 2015) - 16 citations. PMID: 25082625; DOI: 10.1007/s11999-014-3834-0.

6. T.B. Nguyen, G.O. Cron, J.F. Mercier, C. Foottit, C.H. Torres, S. Chakraborty, J. Woulfe, G.H. Jansen, J.M. Caudrelier, J. Sinclair, M.J. Hogan, R.E. Thornhill and I.G. Cameron, Preoperative Prognostic Value of Dynamic Contrast-Enhanced MRI-Derived Contrast Transfer Coefficient and Plasma Volume in Patients with Cerebral Gliomas, American Journal of Neuroradiology 36(1) 63-69 (Jan 2015) – 45 citations. PMID: 24948500; DOI:10.3174/ajnr.A4006.

7. C.A. Longo, P.A. Fried, I.G. Cameron and A.M. Smith, The Long Term Effects of Prenatal Nicotine Exposure on Response Inhibition: An fMRI study of Young Adults, Neurotoxicology and Teratology 39C, 9-18 (Sep-Oct 2013) – 19 citations. PMID: 23743331; DOI: 10.1016/j.ntt.2013.05.007.

8. G. Trudel, E. Coletta, I.G. Cameron, D. Belavý, M. Lecompte, G. Armbrecht, D. Felsenberg, and H. Uhthoff, Resistive Exercises, With and Without Whole Body Vibration, Prevent Vertebral Marrow Fat Accumulation During 60 Days of Head-down Tilt Bed Rest in Men, J. Appl. Physiol. 112(11), 1824-31 (Jun 2012) – 33 citations. PMID: 22442031; DOI: 10.1152/japplphysiol.00029.2012.

9. G.O. Cron, C. Foottit, T.E. Yankeelov, L.I. Avruch, M.E. Schweitzer and I.G. Cameron, Arterial Input Functions Determined from MR Signal Magnitude and Phase for Quantitative Dynamic Contrast Enhanced MR Imaging in the Human Pelvis, Magn. Reson. Med. 66(2), 498-504 (Aug 2011) - 25 citations. PMID: 21360747; DOI: 10.1002/mrm.22856

10. C. Foottit, G.O. Cron, M.J. Hogan, T Nguyen and I.G. Cameron, Determination of the Venous Output Function from MR Signal Phase: Feasibility for Quantitative DCE-MRI in Human Brain, Magn. Reson. Med. 63, 772-781 (Mar 2010) - 32 citations. PMID: 20187184; DOI: 10.1002/mrm.22253