Dr. Ian G. Cameron

Adjunct Research Professor
The Ottawa Hospital - Diagnostic Imaging - Magnetic Resonance Imaging
501 Smyth Road, General Campus
Ottawa, Ontario K1H 8L6
Tel: 
(613) 737 - 8635
Email: 
ICameronattoh [dot] ca

Research Summary

With Magnetic Resonance Imaging (MRI), "pictures" of the inside of the body are obtained noninvasively. The signals from which these MR images are made are generated mainly by 1H nuclei of water. MRI has become a vital part of diagnostic medicine, especially for head, spine and joint imaging. Two areas of MRI research, which are available for graduate student involvement, are diffusion MRI and perfusion MRI. Most of this work will be done on the MR imagers at the Ottawa Hospital.

Contrast between tissues in an MR image is a result of differences in inherent tissue parameters such as NMR relaxation times or water diffusion coefficients (D) between tissues, however, the physics of exactly how these processes contribute to the contrast is often unclear. MR diffusion measurements are rich in information about the microscopic environment of the cells. The challenge is to extract this information and display it in a meaningful way. Currently our focus is on separating the intracellular behaviour from the extracelluar dynamics for human brain white matter in vivo and to study the exchange of water between these two environments.

Currently, MR techniques for measuring blood perfusion (slow blood flow through capillaries) are qualitative but there is a clinical need for quantitative brain perfusion MRI, especially as it pertains to stroke. That is the goal of this project.

Publications/Presentations

  1. Smith AM, Longo CA, Fried PA, Hogan MJ, Cameron I. Effects of marijuana on visuospatial working memory: an fMRI study in young adults (2010)
  2. Foottit C, Cron GO, Hogan MJ, Nguyen TB, Cameron I.Determination of the venous output function from MR signal phase: feasibility for quantitative DCE-MRI in human brain. (2010)
  3. Smith AM, Walker LA, Freedman MS, DeMeulemeester C, Hogan MJ, Cameron I . fMRI investigation of disinhibition in cognitively impaired patients with multiple sclerosis. (2009)
  4. Caudrelier JM, Vermandel M, Betrouni N, Nyiri B, Cameron I, Rousseau J. Towards an accurate and robust method based on fuzzy logic principles for the reconstruction and quantification of large volumes from MR and CT images. (2008)
  5. Gómez-Laberge C, Adler A, Cameron I, Nguyen TB, Hogan MJ. Selection criteria for the analysis of data-driven clusters in cerebral FMRI. (2008)
  6. A.M. Smith, P.A. Fried, M.J. Hogan and I.G. Cameron, Effects of Prenatal Marijuana on Visuospatial Working Memory: An fMRI Study in Young Adults, Neurotoxicology and Teratology 28(2), 286-95 (2006).
  7. A. Cardenas-Blanco, M. Nezamzadeh, C. Foottit, I.G. Cameron, "Accurate Noise Bias Correction Applied to Individual Pixels", International Society of Magnetic Resonance in Medicine, Berlin, May 2007.
  8. C. Foottit, G. Cron, I.G. Cameron, Noise Bias Correction Improves the Accuracy of Low SNR Dynamic Contrast Enhanced Perfusion MRI, Canadian Organization of Medical Physicists, Toronto, Oct. 2007.
  9. M. Nezamzadeh and I.G.Cameron, "A New Rician Noise Bias Correction", International Society of Magnetic Resonance in Medicine, Seattle, (2006).
  10. M. Nezamzadeh and I.G. Cameron, "Rician Noise Corrected and Multi-Component Analyzed Diffusion Signal Decays for Human Brain Tissue in vivo at High b-values", International Society of Magnetic Resonance in Medicine, Seattle, (2006).
  11. M. Nezamzadeh and I.G. Cameron, "Diffusion Studies of Human Brain Tissue in vivo by MRI", Canadian Organization of Physicists in Medicine, Hamilton, (2005).
  12. I.G. Cameron, "Medical Imaging in Ottawa: From Pinhole to 3D and Beyond", R. L. Clarke Symposium in Celebration of 15 Years of the Ottawa Medical Physics Institute, Invited Speaker, Carleton University, Ottawa, (2005).