OMPI Seminar and Social Outing: Iymad Mansour and Balazs Nyiri

Printer-friendly version
Date: 
Thursday, February 15, 2018

Time: 3:30 - 5:00 pm - Refreshments start at 3:15 pm.

Location: Herzberg Building Room 4351, Carleton University.

 Presentations:

1) "Development of a mailed audit protocol for Canada using Alanine dosimeters"

by Iymad Mansour, MSc student, National Research Council and Carleton University

Supervisor: Dr. Malcolm McEwen

Abstract: The National Research Council of Canada (NRC) is currently in the process of developing a mailed audit system using alanine dosimeters. The intention is to offer an on-demand dosimetry service that would provide an independent check on the dose measurements of each Canadian cancer center and thus ensure consistency of treatment across the country. The focus of this talk will be on the development of a clinically applicable alanine dosimetry protocol. Alanine, which was originally developed for dosimetry at the kGy level, has a series of hurdles when considering clinically applicable dosimetry caused by both the readout procedure as well as pellet handling conditions. To achieve a mailed dosimetry service with the targeted sub 1% uncertainty a robust protocol must be developed in order to mitigate these sources of error.

 

2) "Investigations towards Raman Spectroscopy based blood dosimetry"

by Dr. Balazs Nyiri

The Ottawa Hospital Cancer Centre

Abstract: Raman spectroscopy has recently gained interest for providing biochemical information using a label-free, non-invasive approach. It is non-destructive and applicable on all sample types with minimal sample volume requirement and  has successfully been applied in recent years, among others, in biological, medical, and food industry applications. It also offers portability for the real-time assessment of biochemical changes, a feature most welcome in  clinical and in-field applications.

Here, we present work towards the development of a novel approach to identify Raman spectral features in blood that are modified by radiation exposure. Whole blood, lysed blood and isolated white blood cells were used for initial assessment. A workflow from sample handling to analysis was established. A pilot study was conducted using freshly drawn blood from 8 healthy donors.  The blood was ex-vivo irradiated at doses ranging from 0-5 Gy. Three hours post-irradiation, the samples were frozen to lyse cellular contents.  Each sample was analyzed on a commercial portable Raman spectrometer system. The initial results are promising and show convincing evidence of discrimination between blood samples of different radiation doses using multivariate statistical analysis methods. However, further work is needed to optimize spectrum quality and measurement efficiency. For this purpose, we are currently investigating the possibility of developing a "flow-cell" attachment to the portable Raman system. With this we hope to minimize sample degradation thereby improving spectrum quality, also increase reproducibility, and data collection efficiency.


Social event details (a message from Nick Majtenyi)

With a recent change in the weather predicted for Thursday the canal is CLOSED overnight on Wednesday for maintenance, and may not be open Thursday for skating. Instead, let's all meet up for beer closer to Carleton at The Senate Tavern on Bank (1159 Bank Street, near the intersection of Belmont & Bank) following the seminar! It has its own stop off the #7 bus or about a 20 minute walk away. Please feel free to bring friends, significant others, or anyone you'd like for this great opportunity to socialize with other OMPI members!

I hope to see everyone there!

 

Nick