OMPI Seminar: Nelson Miksys and Ian Cameron and Social Event

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Thursday, February 25, 2016

Time: 3:30-5:00 pm. Refreshments start at 3:15 pm.

Location: Herzberg Building Room 4351, Carleton University.


1. Patient-specific Monte Carlo dose calculations for Pd-103 permanent implant breast brachytherapy

By Nelson Miksys, Carleton University.

Abstract: This talk will summarize a recent investigation of patient-specific Monte Carlo dose calculations for patients who received Pd-103 permanent implant breast brachytherapy at The Ottawa Hospital Cancer Centre. One purpose of this work is to compare retrospectively calculated dose distributions between the clinical AAPM TG-43 water-based approach and the Monte Carlo method which models patient-specific anatomy. DVH-metrics evaluated in the PTV and the skin can differ by up to 27% and 48% respectively between TG-43 and Monte Carlo, which may help inform a future reassessment of prescription dose and OAR dose limits. A second purpose of this
investigation is to explore the sensitivity on Monte Carlo dose calculations from the necessary modelling choices required to derive virtual patient-specific models. The observed sensitivities motivate the development of clear consensus modelling guidelines to build upon the limited recommendations provided in AAPM TG-186. Towards this goal, we present modelling choice suggestions based on our experiences with patient-specific Monte Carlo dose calculations of breast brachytherapy.


2. Using MRI to assess microvascular blood flow

By Ian Cameron, The Ottawa Hospital, and Physics Deartment at Carleton University

Abstract: Detailed knowledge of microvascular flow can be very useful for the assessment of certain pathologies.  We have been working with a radiologist at The Ottawa Hospital for the past several years to develop better ways of measuring microvascular parameters for gliomas using MRI. There are several MRI techniques that are sensitive to microvascular flow. The more established methods track contrast agent as it flows through the tissue; other approaches do not require the injection of a contrast agent. In the first part of my talk I will briefly introduce these different methods, giving relative merits and shortcomings of each.  The focus of the talk will then shift to a discussion of Diffusion Weight Imaging and how it could potentially be used to obtain information about slow blood
flow in tissues.  While it is known that these measurements are sensitive to slow flow, it is not known how the parameters obtained with this approach relate to the parameters from the other MRI approaches. The goal of the research project is to investigate this relationship.


3. Social event announcement from Liz:

Calling all Ottawa physicists (and friends!),


Although the weather is still making the availability of canal skating a prediction with large associated uncertainty, Id like to invite you all to come out for a Winter OMPI Social following the next seminar. Should the canal be open, athletic enthusiasts are invited to join me for a skate from Carleton down to Pretoria, followed by drinks and food at the Royal Oak at Pretoria.

For those of us who are not interested in freezing their toes off, I will make the reservation at the Royal Oak early enough that you can proceed straight there from the seminar. Please feel free to bring friends, significant others, they typically do an excellent job of balancing the physics-over-beer conversation with all the other things the rest of the world is interested in.

When? Thurs Feb 25th, 5:45pm onwards

Where? Royal Oak Pretoria, (website gives address as Canal 221 Echo Drive)

What to do? Please RSVP to me eortonattoh [dot] on [dot] ca (eortonattoh [dot] on [dot] ca) so I can estimate the reservation size

I have an extra pair of size 8 mens (~ size 9 womens) hockey skates in case anyone needs to borrow them.


Looking forward to seeing you!