Elizabeth Orton, Sangeeta Murugkar and winter special event

Printer-friendly version
Thursday, January 23, 2014
3:30 - 5 pm
Room RPB 205B (boardroom), Health Canada, 775 Brookfield Road
Elizabeth Orton and Sangeeta Murugkar


1. "Automated detection of extra-cardiac interference in Rubidium-82 PET myocardial perfusion imaging"
Elizabeth Orton - Carleton University

Abstract: In nuclear cardiology, myocardial perfusion imaging, MPI, is used to reflect the heart muscle's regional blood supply and it is widely applied for diagnosis and risk stratification of coronary artery disease. MPI studies produced with PET and the radio-labeled cardiac perfusion tracer rubidium-82 chloride, Rb-82, frequently show tracer uptake not only in the myocardium but also in the stomach wall and spleen. When the proximity of these structures to the myocardium is combined with local cardiac and respiratory motion and the spatial resolution of the imaging modality, the result can be an unknown amount of extra-cardiac signal contributing to the area of the image designated as myocardium. An estimated 10% of Rb-82 PET MPI studies suffer from extra-cardiac interference that impacts clinical image interpretation. An algorithm for quickly and consistently detecting extra-cardiac interference in Rb-82 PET MPI will be presented, along with validation of the algorithm against 100 expert-read studies, and finally, algorithm-based prevalence results from 2560 Rb-82 PET MPI studies from the 2011 - 2012 University of Ottawa Heart Institute database.

2. "Optical Molecular Imaging in Biomedicine"
Sangeeta Murugkar - Carleton University

Abstract: Optical molecular imaging (OMI) couples optical imaging with different methods of enhancing chemical contrast at the molecular level. It promises to revolutionize the field of medicine due to its comparatively lower cost, high sensitivity and resolution combined with minimal toxicity. The development and applications of a label-free OMI technique based on coherent anti-Stokes Raman scattering (CARS) will be discussed in this talk. I will describe the design and implementation of the first fiber-optic miniaturized multimodal CARS microscope for the in vivo study of spinal cord disorders in small animals. I will share my vision of label-free OMI based on this technology for early disease detection in the clinic.

The talks are followed by an evening skate on the Rideau canal, ending with a social gathering at the Royal Oak at pretoria bridge (map). Please RSVP to Elizabeth Orton (Eorton [at] ottawaheart [dot] ca) if you'll be joining us for skating and/or meeting us at the pub.